Simultaneous detection of multiple mRNAs and proteins in bovine IVD cells and tissue

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In vitro diagnostics for screening the blood provide: the brand new European regulation for IVD and the WHO IVD prequalification programme

Blood transfusion stays a routine life-saving medical process that helps change blood misplaced because of surgical procedure, harm or illness. The standard of transfused blood is essential on this course of as blood donors should be freed from transfusion-transmissible infections and donated blood ought to be appropriate to that of the recipient. The standard of donated blood might be affected by the standard of in vitro diagnostic medical units (IVDs) used within the screening course of.

Consequently, the necessity for high-quality, protected and well-performing IVDs to be used in transfusion drugs arises, accompanied by the necessity for tight laws on this area. Within the European Union, the brand new IVD Regulation will change the present IVD Directive inside a five-year transitional interval. Producers of IVDs are anticipated to totally adjust to the brand new Regulation by 26 Could 2022.

On this evaluation, we handle the most important variations regarding advertising authorization and testing between this new Regulation and its predecessor. We additional current the principle parts of the prequalification evaluation launched by the WHO for IVDs, together with disease-specific IVDs for blood screening laboratories.

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Neuron Specific Enolase

MBS460257-01mg 0.1mg
EUR 320

Neuron Specific Enolase

MBS460257-5x01mg 5x0.1mg
EUR 1390

Human Neuron Specific Enolase ELISA kit

E01A6166 96T
EUR 700
Description: ELISA

Human Neuron Specific Enolase ELISA kit

E01N0025-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Neuron Specific Enolase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Neuron Specific Enolase ELISA kit

E01N0025-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Neuron Specific Enolase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Neuron Specific Enolase ELISA kit

E01N0025-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Neuron Specific Enolase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Neuron Specific Enolase ELISA Kit

MBS045924-10x96StripWells 10x96-Strip-Wells
EUR 6725

Human Neuron Specific Enolase ELISA Kit

MBS045924-48StripWells 48-Strip-Wells
EUR 550

Human Neuron Specific Enolase ELISA Kit

MBS045924-5x96StripWells 5x96-Strip-Wells
EUR 3420

Human Neuron Specific Enolase ELISA Kit

MBS045924-96StripWells 96-Strip-Wells
EUR 765

Human Neuron Specific Enolase (NSE) ELISA

LF-EK0169 1×96T
EUR 723.6

Human Neuron Specific Enolase ELISA Kit

MBS728595-48StripWellsCompetitive 48-Strip-Wells-(Competitive)
EUR 485

Human Neuron Specific Enolase ELISA Kit

MBS728595-48StripWellsSandwich 48-Strip-Wells-(Sandwich)
EUR 485

Human Neuron Specific Enolase ELISA Kit

MBS728595-5x96StripWellsCompetitive 5x96-Strip-Wells-(Competitive)
EUR 3020

Human Neuron Specific Enolase ELISA Kit

MBS728595-96StripWellsCompetitive 96-Strip-Wells-(Competitive)
EUR 690

Human Neuron Specific Enolase ELISA Kit

MBS728595-96StripWellsSandwich 96-Strip-Wells-(Sandwich)
EUR 690

Neuron Specific Enolase (NSE), Human Brain

MBS173164-0025mg 0.025mg
EUR 220

Neuron Specific Enolase (NSE), Human Brain

MBS173164-01mg 0.1mg
EUR 450

Neuron Specific Enolase (NSE), Human Brain

MBS173164-1mg 1mg
EUR 3300

Neuron Specific Enolase (NSE), Human Brain

MBS173164-5x1mg 5x1mg
EUR 14635

Neuron Specific Enolase 2 Human Recombinant

rAP-1076 Inquiry Ask for price

Neuron Specific Enolase (NSE)

CH22126 100 ul of serum
EUR 490.8

Neuron Specific Enolase (NSE)

GWB-50534F 0.1 mg Ask for price

Neuron Specific Enolase (NSE)

GWB-87922F 0.1 mg Ask for price

Neuron Specific Enolase (NSE)

MBS6489899-01mL 0.1mL
EUR 535

Neuron Specific Enolase (NSE)

MBS6489899-5x01mL 5x0.1mL
EUR 2260

Neuron Specific Enolase (NSE)

MBS635201-01mg 0.1mg
EUR 1080

Neuron Specific Enolase (NSE)

MBS635201-5x01mg 5x0.1mg
EUR 4700

Neuron Specific Enolase (NSE)

MBS634362-01mg 0.1mg
EUR 1365

Neuron Specific Enolase (NSE)

MBS634362-5x01mg 5x0.1mg
EUR 5910

NEURON SPECIFIC ENOLASE [NSE]

MBS615484-05mL 0.5mL
EUR 820

NEURON SPECIFIC ENOLASE [NSE]

MBS615484-5x05mL 5x0.5mL
EUR 3535

Neuron Specific Enolase (NSE)

MBS318316-01mg 0.1mg
EUR 1105

Neuron Specific Enolase (NSE)

MBS318316-5x01mg 5x0.1mg
EUR 4720

Neuron Specific Enolase (NSE)

MBS555976-01mL 0.1mL
EUR 410

Neuron Specific Enolase (NSE)

MBS555976-5x01mL 5x0.1mL
EUR 1705

Human Enolase Neuron Specific ELISA Kit

IHUNSEKT each
EUR 667
Description: Human Enolase Neuron Specific ELISA Kit

Human Enolase, Neuron Specific (NSE) Protein

20-abx066423
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Enolase, Neuron Specific (NSE) Protein

20-abx066426
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Enolase, Neuron Specific (NSE) Protein

abx066423-100g 100 µg
EUR 475

Human Enolase, Neuron Specific (NSE) Protein

abx066423-10g 10 µg
EUR 200

Human Enolase, Neuron Specific (NSE) Protein

abx066423-50g 50 µg
EUR 337.5

Human Enolase, Neuron Specific (NSE) Protein

abx066426-100g 100 µg
EUR 475

Human Enolase, Neuron Specific (NSE) Protein

abx066426-10g 10 µg
EUR 200

Human Enolase, Neuron Specific (NSE) Protein

abx066426-50g 50 µg
EUR 337.5

Human Enolase, Neuron Specific (ENO2) CLIA Kit

20-abx491609
  • Ask for price
  • Ask for price
  • Ask for price
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human NSE (Neuron Specific Enolase) ELISA Kit

EKE60659-5x96T 5x96T
EUR 2667.6

Human NSE (Neuron Specific Enolase) ELISA Kit

EKE60659-96T 96T
EUR 561.6

Human NSE(Neuron Specific Enolase) ELISA Kit

RE3008H-48wells 48 wells
EUR 116.55

Human NSE(Neuron Specific Enolase) ELISA Kit

RE3008H-96wells 96 wells
EUR 161.55

Human NSE(Neuron Specific Enolase) ELISA Kit

SYP-H0264-48wellsplate 48 wells plate
EUR 180

Human NSE(Neuron Specific Enolase) ELISA Kit

SYP-H0264-96wellsplate 96 wells plate
EUR 220

Human NSE(Neuron Specific Enolase) ELISA Kit

RE3008H-48wellsplate 48 wells plate
EUR 126

Human NSE(Neuron Specific Enolase) ELISA Kit

RE3008H-96wellsplate 96 wells plate
EUR 180

Human Neuron Specific Enolase (NSE) ELISA (4X96T)

LF-EK0170 4×96T
EUR 2454

Human Enolase, Neuron Specific (ENO2) ELISA Kit

20-abx152555
  • Ask for price
  • Ask for price
  • Ask for price
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Enolase, Neuron Specific (ENO2) ELISA Kit

abx253091-96tests 96 tests
EUR 877.2

Human Enolase, Neuron Specific (ENO2) ELISA Kit

abx573286-96tests 96 tests
EUR 877.2

Neuron Specific Enolase (NSE) from Human Brain

GWB-7C3F42 1 mg Ask for price

Human Neuron Specific Enolase (NSE) ELISA (10X96T)

LF-EK0171 10×96T
EUR 5380.8

Human Neuron Specific Enolase (NSE) ELISA (20X96T)

LF-EK0172 20×96T
EUR 9369.6

Neuron Specific Enolase Protein

abx060902-100ug 100 ug
EUR 1387.2

Neuron Specific Enolase Protein

abx060902-100g 100 µg Ask for price

Neuron Specific Enolase Protein

abx060902-10g 10 µg
EUR 1862.5

Neuron Specific Enolase Protein

abx060902-50g 50 µg Ask for price

NSE (Enolase2, gamma-Enolase, body, Enolase2, Neuron Specific Enolase, Enolase 2 gamma Neuronal, Neural Enolase, NSE, Neuron Specific gamma Enolase) (HRP)

MBS6262616-01mL 0.1mL
EUR 995

NSE (Enolase2, gamma-Enolase, body, Enolase2, Neuron Specific Enolase, Enolase 2 gamma Neuronal, Neural Enolase, NSE, Neuron Specific gamma Enolase) (HRP)

MBS6262616-5x01mL 5x0.1mL
EUR 4335

NSE (Enolase2, gamma-Enolase, body, Enolase2, Neuron Specific Enolase, Enolase 2 gamma Neuronal, Neural Enolase, NSE, Neuron Specific gamma Enolase) (PE)

MBS6263127-01mL 0.1mL
EUR 995

NSE (Enolase2, gamma-Enolase, body, Enolase2, Neuron Specific Enolase, Enolase 2 gamma Neuronal, Neural Enolase, NSE, Neuron Specific gamma Enolase) (PE)

MBS6263127-5x01mL 5x0.1mL
EUR 4335

NSE (Enolase2, gamma-Enolase, body, Enolase2, Neuron Specific Enolase, Enolase 2 gamma Neuronal, Neural Enolase, NSE, Neuron Specific gamma Enolase) (AP)

MBS6260576-01mL 0.1mL
EUR 995

NSE (Enolase2, gamma-Enolase, body, Enolase2, Neuron Specific Enolase, Enolase 2 gamma Neuronal, Neural Enolase, NSE, Neuron Specific gamma Enolase) (AP)

MBS6260576-5x01mL 5x0.1mL
EUR 4335

NSE (Enolase2, gamma-Enolase, body, Enolase2, Neuron Specific Enolase, Enolase 2 gamma Neuronal, Neural Enolase, NSE, Neuron Specific gamma Enolase) (APC)

MBS6261087-01mL 0.1mL
EUR 995

NSE (Enolase2, gamma-Enolase, body, Enolase2, Neuron Specific Enolase, Enolase 2 gamma Neuronal, Neural Enolase, NSE, Neuron Specific gamma Enolase) (APC)

MBS6261087-5x01mL 5x0.1mL
EUR 4335

Neuron Specific Enolase, Recombinant Human Protein

MBS555623-0025mg 0.025mg
EUR 320

Neuron Specific Enolase, Recombinant Human Protein

MBS555623-5x0025mg 5x0.025mg
EUR 1300

Neuron Specific Enolase Antibody

F48200-0.4ML 0.4 ml
EUR 322.15
Description: NSE is one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha to gamma enolase occurs in neural tissue during development in rats and primates. [Wiki]

Neuron Specific Enolase Antibody

GWB-39ACE9 1 mg Ask for price

Neuron Specific Enolase Antibody

GWB-5A16BD 0.2 mg Ask for price

Neuron Specific Enolase Antibody

GWB-5D7D7D 0.1 ml Ask for price

Neuron Specific Enolase Antibody

GWB-20CCC7 1 mg Ask for price

Neuron Specific Enolase, Antibody

GWB-2648D8 1 ml Ask for price

Neuron Specific Enolase Antibody

GWB-278967 0.2 mg Ask for price

Neuron Specific Enolase Antibody

GWB-1C6640 1 mg Ask for price

Neuron Specific Enolase Antibody

GWB-931EEF 1 mg Ask for price

Neuron Specific Enolase Antibody

GWB-6DF4F0 0.2 mg Ask for price

Neuron Specific Enolase Antibody

GWB-7A81C1 1 mg Ask for price

Neuron Specific Enolase, Antibody

GWB-B690B7 7 ml Ask for price

Neuron Specific Enolase Antibody

GWB-BAA2AA 1 mg Ask for price

Neuron Specific Enolase Antibody

GWB-D41123 1 ml Ask for price

Neuron Specific Enolase antibody

MBS226412-01mL 0.1mL
EUR 485

Neuron Specific Enolase antibody

MBS226412-5x01mL 5x0.1mL
EUR 2015

NSE (Enolase2, gamma-Enolase, body, Enolase2, Neuron Specific Enolase, Enolase 2 gamma Neuronal, Neural Enolase, NSE, Neuron Specific gamma Enolase) (Biotin)

MBS6261597-01mL 0.1mL
EUR 995

NSE (Enolase2, gamma-Enolase, body, Enolase2, Neuron Specific Enolase, Enolase 2 gamma Neuronal, Neural Enolase, NSE, Neuron Specific gamma Enolase) (Biotin)

MBS6261597-5x01mL 5x0.1mL
EUR 4335

NSE (Enolase2, gamma-Enolase, body, Enolase2, Neuron Specific Enolase, Enolase 2 gamma Neuronal, Neural Enolase, NSE, Neuron Specific gamma Enolase) (FITC)

MBS6262106-01mL 0.1mL
EUR 995

NSE (Enolase2, gamma-Enolase, body, Enolase2, Neuron Specific Enolase, Enolase 2 gamma Neuronal, Neural Enolase, NSE, Neuron Specific gamma Enolase) (FITC)

MBS6262106-5x01mL 5x0.1mL
EUR 4335

ENO2 (Enolase 2, Neuron Specific Enolase, NSE) (AP)

MBS6415892-01mL 0.1mL
EUR 950

ENO2 (Enolase 2, Neuron Specific Enolase, NSE) (AP)

MBS6415892-5x01mL 5x0.1mL
EUR 4120

ENO2 (Enolase 2, Neuron Specific Enolase, NSE) (PE)

MBS6415902-01mL 0.1mL
EUR 950

ENO2 (Enolase 2, Neuron Specific Enolase, NSE) (PE)

MBS6415902-5x01mL 5x0.1mL
EUR 4120

Recombinant Human Enolase, Neuron Specific (NSEH)

MBS283699-01mg 0.1mg
EUR 440

Recombinant Human Enolase, Neuron Specific (NSEH)

MBS283699-05mg 0.5mg
EUR 1200

Recombinant Human Enolase, Neuron Specific (NSEH)

MBS283699-1mg 1mg
EUR 1665

Recombinant Human Enolase, Neuron Specific (NSEH)

MBS283699-5x1mg 5x1mg
EUR 7480

ENO2 (Enolase 2, Neuron Specific Enolase, NSE) (APC)

MBS6415893-01mL 0.1mL
EUR 950

ENO2 (Enolase 2, Neuron Specific Enolase, NSE) (APC)

MBS6415893-5x01mL 5x0.1mL
EUR 4120

ENO2 (Enolase 2, Neuron Specific Enolase, NSE) (HRP)

MBS6415896-01mL 0.1mL
EUR 950

ENO2 (Enolase 2, Neuron Specific Enolase, NSE) (HRP)

MBS6415896-5x01mL 5x0.1mL
EUR 4120

Neuron Specific Enolase (NSE) 98%

GWB-104D9E 1 mg Ask for price

Neuron Specific Enolase (NSE) (PE)

MBS6129483-01mL 0.1(mL
EUR 1095

Neuron Specific Enolase (NSE) (PE)

MBS6129483-5x01mL 5x0.1mL
EUR 4775

Neuron Specific Enolase (NSE) (PE)

MBS6129484-01mL 0.1(mL
EUR 1195

Neuron Specific Enolase (NSE) (PE)

MBS6129484-5x01mL 5x0.1mL
EUR 5220

Neuron Specific Enolase (NSE) (PE)

MBS6129485-01mL 0.1(mL
EUR 1095

Neuron Specific Enolase (NSE) (PE)

MBS6129485-5x01mL 5x0.1mL
EUR 4775

Neuron Specific Enolase (NSE) (AP)

MBS6126387-01mL 0.1(mL
EUR 1095

Neuron Specific Enolase (NSE) (AP)

MBS6126387-5x01mL 5x0.1mL
EUR 4775

Neuron Specific Enolase (NSE) (AP)

MBS6126388-01mL 0.1(mL
EUR 1195

Neuron Specific Enolase (NSE) (AP)

MBS6126388-5x01mL 5x0.1mL
EUR 5220

Neuron Specific Enolase (NSE) (AP)

MBS6126389-01mL 0.1(mL
EUR 1095

Neuron Specific Enolase (NSE) (AP)

MBS6126389-5x01mL 5x0.1mL
EUR 4775

Neuron Specific Enolase (NSE) (AP)

MBS6489890-01mL 0.1mL
EUR 535

Neuron Specific Enolase (NSE) (AP)

MBS6489890-5x01mL 5x0.1mL
EUR 2260

Neuron Specific Enolase (NSE) (PE)

MBS6489900-01mL 0.1mL
EUR 535

Neuron Specific Enolase (NSE) (PE)

MBS6489900-5x01mL 5x0.1mL
EUR 2260

MAb to Neuron Specific Enolase

MBS311543-1mg 1mg
EUR 715

MAb to Neuron Specific Enolase

MBS311543-5x1mg 5x1mg
EUR 3035

MAb to Neuron Specific Enolase

MBS311547-1mg 1mg
EUR 715

MAb to Neuron Specific Enolase

MBS311547-5x1mg 5x1mg
EUR 3035

MAb to Neuron Specific Enolase

MBS311549-1mg 1mg
EUR 605

MAb to Neuron Specific Enolase

MBS311549-5x1mg 5x1mg
EUR 2640

MAb to Neuron Specific Enolase

MBS311561-1mg 1mg
EUR 605

MAb to Neuron Specific Enolase

MBS311561-5x1mg 5x1mg
EUR 2640

MAb to Neuron Specific Enolase

MBS311563-1mg 1mg
EUR 715

MAb to Neuron Specific Enolase

MBS311563-5x1mg 5x1mg
EUR 3035

MAb to Neuron Specific Enolase

MBS311574-1mg 1mg
EUR 715

MAb to Neuron Specific Enolase

MBS311574-5x1mg 5x1mg
EUR 3035

Neuron Specific Enolase (NSE) (AP)

MBS6241760-01mL 0.1(mL
EUR 1005

Neuron Specific Enolase (NSE) (AP)

MBS6241760-5x01mL 5x0.1mL
EUR 4370

Neuron Specific Enolase (NSE) (PE)

MBS6244424-01mL 0.1(mL
EUR 1005

Neuron Specific Enolase (NSE) (PE)

MBS6244424-5x01mL 5x0.1mL
EUR 4370

Human Enolase, Neuron Specific (NSE) ELISA Kit

DLR-NSE-Hu 96T
EUR 422
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Enolase, Neuron Specific (NSE) ELISA Kit

DLR-NSE-Hu-48T 48T
EUR 574.8
Description: A sandwich quantitative ELISA assay kit for detection of Human Enolase, Neuron Specific (NSE) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Enolase, Neuron Specific (NSE) ELISA Kit

DLR-NSE-Hu-96T 96T
EUR 745.2
Description: A sandwich quantitative ELISA assay kit for detection of Human Enolase, Neuron Specific (NSE) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Enolase, Neuron Specific (NSE) ELISA Kit

DL-NSE-Hu 96T
EUR 402
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Enolase, Neuron Specific (NSE) ELISA Kit

EKN45014-48T 48T
EUR 341.04

Human Enolase, Neuron Specific (NSE) ELISA Kit

EKN45014-5x96T 5x96T
EUR 2314.2

Human Enolase, Neuron Specific (NSE) ELISA Kit

EKN45014-96T 96T
EUR 487.2

Human Enolase, Neuron Specific (NSE) ELISA Kit

EKU03903-48T 48T
EUR 500.5

Human Enolase, Neuron Specific (NSE) ELISA Kit

EKU03903-5x96T 5x96T
EUR 3396.25

Human Enolase, Neuron Specific (NSE) ELISA Kit

EKU03903-96T 96T
EUR 715

Human Enolase, Neuron Specific (NSE) ELISA Kit

EK15827 96Т
EUR 768

Human NSE(Enolase, Neuron Specific) ELISA Kit

ELK2587-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human NSE. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human NSE. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human NSE, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human NSE in the samples is then determined by comparing the OD of the samples to the standard curve.

Human NSE(Enolase, Neuron Specific) ELISA Kit

ELK2587-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human NSE. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human NSE. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human NSE, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human NSE in the samples is then determined by comparing the OD of the samples to the standard curve.

Human Enolase, Neuron Specific ELISA Kit (NSE)

RK01966 96 Tests
EUR 280

Human Enolase, Neuron Specific (NSE) ELISA Kit

RDR-NSE-Hu-48T 48T
EUR 432.39
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Human Enolase, Neuron Specific (NSE) ELISA Kit

RDR-NSE-Hu-48Tests 48 Tests
EUR 600

Human Enolase, Neuron Specific (NSE) ELISA Kit

RDR-NSE-Hu-96T 96T
EUR 617.72
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Human Enolase, Neuron Specific (NSE) ELISA Kit

RDR-NSE-Hu-96Tests 96 Tests
EUR 830.4

Human Enolase, Neuron Specific (NSE) ELISA Kit

RD-NSE-Hu-48T 48T
EUR 411.8
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Human Enolase, Neuron Specific (NSE) ELISA Kit

RD-NSE-Hu-48Tests 48 Tests
EUR 573.6

Human Enolase, Neuron Specific (NSE) ELISA Kit

RD-NSE-Hu-96T 96T
EUR 588.3
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Human Enolase, Neuron Specific (NSE) ELISA Kit

RD-NSE-Hu-96Tests 96 Tests
EUR 794.4

Human Enolase, Neuron Specific (NSE) ELISA Kit

SEA537Hu-10x96wellstestplate 10x96-wells test plate
EUR 5128.02
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Enolase, Neuron Specific (NSE) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Enolase, Neuron Specific (NSE) ELISA Kit

SEA537Hu-1x48wellstestplate 1x48-wells test plate
EUR 527.48
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Enolase, Neuron Specific (NSE) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Enolase, Neuron Specific (NSE) ELISA Kit

SEA537Hu-1x96wellstestplate 1x96-wells test plate
EUR 702.12
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Enolase, Neuron Specific (NSE) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Simultaneous detection of a number of mRNAs and proteins in bovine IVD cells and tissue with single cell decision 

Goals: Interactions of cells with their neighbors and influences by the encircling extracellular matrix (ECM) is mirrored in a cells transcriptome and proteome. In tissues comprised of heterogeneous cell populations or cells relying on ECM signalling cues similar to these of the intervertebral disc (IVD), this info is obscured or misplaced when cells are pooled for the generally used transcript evaluation by quantitative PCR or RNA sequencing.

As a substitute, these cells require means to analyse RNA transcript and protein distribution at a single cell or subcellular degree to establish completely different cell sorts and capabilities, with out eradicating them from their surrounding signalling cues.

Outcomes: We developed a easy, sequential protocol combining RNA is situ hybridisation (RISH) and immunohistochemistry (IHC) for the simultaneous evaluation of a number of transcripts alongside proteins. This permits one to characterize heterogeneous cell populations on the single cell degree within the pure cell surroundings and signalling context, each in vivo and in vitro. This protocol is demonstrated on cells of the bovine IVD, for transcripts and proteins concerned in mechanotransduction, stemness and cell proliferation.

Conclusions: A easy, sequential protocol combining RISH and IHC is introduced that enables for simultaneous info on RNA transcripts and proteins to characterize cells inside a heterogeneous cell inhabitants and complicated signalling environments similar to these of the IVD.

The brand new IVD Regulation 2017/746: a case examine at a big college hospital laboratory in Belgium demonstrates the necessity for clarification on the levels of freedom laboratories have to make use of lab-developed checks to enhance affected person care

Goals The brand new European In Vitro Diagnostic (IVD) Regulation 2017/746 (IVDR) restricts the usage of lab-developed checks (LDT) after 26th Could 2022. There aren’t any knowledge on the affect of the IVDR on laboratories within the European Union. Strategies Laboratory checks carried out in UZ Leuven have been divided in 4 teams: core laboratory, immunology, particular chemistry, and molecular microbiology testing.

Every check was categorised as Conformité Européenne (CE)-IVD, modified/off-label CE-IVD, business Analysis Use Solely (RUO) or LDT. Every matrix was thought-about a separate check. Outcomes We discovered that 97.6% of the greater than 11.5 million outcomes/yr have been generated with a CE-IVD technique. Of the 922 completely different laboratory checks, nonetheless, solely 41.8% have been CE-IVD, 10.8% modified/off-label CE-IVD, 0.3% RUO, and 47.1% LDT. Off-label CE-IVD was primarily used to check different matrices not lined by the declare of the producer (e.g., pleural or peritoneal fluid). LDTs have been primarily used for particular chemistry, stream cytometry, and molecular testing.

Excluding stream cytometry, the principle causes for the use of 377 LDTs have been lack of a CE-IVD technique (71.9%), analytical necessities (14.3%), and the actual fact the LDT was in use earlier than CE-IVD accessible (11.9%). Conclusions Whereas the big majority of outcomes (97.6%) have been generated with a CE-IVD technique, solely 41.8% of laboratory checks have been CE-IVD. There may be presently no different available on the market for 71.5% of the 537 LDTs carried out in our laboratory which don’t fall inside the scope of the present IVD directive (IVDD). Compliance with the IVDR would require a significant funding of effort and time.

Lack of sensitivity of an IVD/CE-labeled package focusing on the S gene for detection of SARS-CoV-2

Goals: New molecular checks for SARS-CoV-2 are quickly launched in response to the COVID-19 pandemic. The purpose of this examine was to guage the analytical and the scientific efficiency of the VIASURE SARS-CoV-2 S gene RT-PCR Package on the BD Max™ system and to check outcomes with these obtained with the cobas® SARS-CoV-2 check on the cobas® 6800 system.

Strategies: For testing the analytical efficiency, reference materials was used. Scientific samples (n=101) obtained from sufferers with signs appropriate to COVID-19 have been studied. Oro- and nasopharyngeal swabs have been collected through the use of both ESwab™ or UTM™ assortment techniques.

Outcomes: When the analytical efficiency was evaluated, the pattern containing the bottom SARS-CoV-2 focus examined destructive with the VIASURE check whereas outcomes obtained with the cobas® check have been discovered to be concordant with the outcomes anticipated. Six out of the 101 scientific samples (5.9%) confirmed an inhibition with the VIASURE check. When analyzing the remaining 95 scientific samples, 27 have been discovered to be destructive with each assays. Of 68 samples optimistic with the cobas® check, the VIASURE check missed 21 (30.9 %) samples. All of these 21 samples had proven Ct values ≥ 31 with the cobas® 6800 system. Not one of the samples examined optimistic with the VIASURE check and destructive with the cobas® check.

Conclusions: The VIASURE check was impaired by an absence of sensitivity and a comparatively excessive variety of invalid outcomes. When utilizing the VIASURE check for routine testing, a big variety of COVID-19 optimistic samples would have been missed.

Present standing of improvement of methylation biomarkers for in vitro diagnostic IVD functions 

A big quantity of analysis clearly exhibits that disease-related methylation adjustments can be utilized as biomarkers in any respect levels of scientific illness administration, together with threat evaluation and predisposition screening via early diagnostics to personalization of affected person care and monitoring of the relapse and persistent illness. Thus disease-related methylation adjustments are a sexy supply of the biomarkers that may have important affect on precision drugs. Nonetheless, the interpretation of the analysis findings in methylation biomarkers discipline to scientific observe is on the very least not passable. That’s primarily as a result of the proof generated in analysis research indicating the utility of the disease-related methylation change to predict scientific end result is in majority of the instances not ample to postulate the diagnostic use of the biomarker.

The analysis research should be adopted by well-designed and systematic investigations of scientific utility of the biomarker that produce knowledge of ample high quality to fulfill regulatory approval for the check for use to make clinically legitimate resolution.

On this evaluation, we describe methylation-based IVD checks presently authorised for IVD use or on the superior levels of the event for the diagnostic use. For every of these checks, we analyze the applied sciences that the check makes use of for methylation detection in addition to describe the kinds of the scientific research that have been carried out to point out scientific validity of the check and warrant regulatory approval. The examples reviewed right here ought to assist with planning of scientific investigations and supply of the scientific proof required for the regulatory approval of potential methylation biomarker primarily based IVD checks.

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